Author dc.contributor.author | Sváb Domonkos | |
Author dc.contributor.author | Falgenhauer Linda | |
Author dc.contributor.author | Horváth Balázs | |
Author dc.contributor.author | Maróti Gergely | |
Author dc.contributor.author | Falgenhauer Jane | |
Author dc.contributor.author | Chakraborty Trinad | |
Author dc.contributor.author | Tóth István | |
Availability Date dc.date.accessioned | 2023-02-16T13:51:40Z | |
Availability Date dc.date.available | 2023-02-16T13:51:40Z | |
Release dc.date.issued | 2021 | |
Issn dc.identifier.issn | 1664-302X | |
uri dc.identifier.uri | http://hdl.handle.net/20.500.12944/20011 | |
Abstract dc.description.abstract | Shigella dysenteriae are significant agents of bacillary dysentery, accounting for a considerable number of illnesses with high morbidity worldwide. The Shiga toxin (Stx) encoded by a defective prophage is the key virulence factor of S. dysenteriae type 1 (SD1) strains. Here we present the full genome sequence of an SD1 strain HNCMB 20080 isolated in 1954, compare it to other sequenced SD1 genomes, and assess the diversity of Stx-prophages harbored by previously sequenced SD1 strains. The genome of HNCMB 20080 consists of a chromosome sized 4,393,622 bp containing 5,183 CDSs, as well as two small plasmids. Comparative genomic analysis revealed a high degree of uniformity among SD1 genomes, including the structure of Stx prophage regions, which we found to form two subgroups termed PT-I and PT-II. All PT-I strains are members of the sequence type (ST) 146 or ST260, while the only PT-II harboring strain, Sd1617 proved to be ST untypeable. In accordance with data from previous reports, the Stx1 prophage could not be induced from HNCMB 20080. Our cumulative data do not support the notion that stx-harboring phages in STEC are derived from historical SD1 isolates. | |
Language dc.language | en | |
Keywords dc.subject | Shigella dysenteriae serotype 1 | |
Keywords dc.subject | Stx1 prophage | |
Keywords dc.subject | complete genome | |
Keywords dc.subject | comparative genomics | |
Keywords dc.subject | phylogeny | |
Title dc.title | Genome Analysis of a Historical Shigella Dysenteriae Serotype 1 Strain Carrying aConserved Stx Prophage Region | |
Type dc.type | folyóiratcikk | |
Date Change dc.date.updated | 2023-02-15T14:48:48Z | |
Version dc.description.version | kiadói | |
dc.rights.accessRights | nyílt hozzáférésű | |
Doi ID dc.identifier.doi | 10.3389/fmicb.2020.614793 | |
Discipline Discipline + dc.subject.discipline | Természettudományok | |
dc.subject.sciencebranch | Természettudományok/Biológiai tudományok | |
MTMT ID dc.identifier.mtmt | 31801318 | |
dc.identifier.journalTitle | Frontiers in Microbiology | |
dc.identifier.journalVolume | 11 | |
Scope dc.format.page | 1-8 | |
Wos ID dc.identifier.wos | 000609253000001 | |
ID Scopus dc.identifier.scopus | 85099727875 | |
dc.identifier.journalAbbreviatedTitle | FRONT MICROBIOL | |
Release Date dc.description.issuedate | 2021 | |
Pubmed ID dc.identifier.pubmed | 33488558 | |
Author institution dc.contributor.department | Állatorvos-tudományi Intézet | |
Author institution dc.contributor.department | Növénybiológiai Intézet | |
Author institution dc.contributor.department | Vízellátási és Csatornázási Tanszék | |
Author institution dc.contributor.department | Állatorvostudományi Doktori Iskola | |
Author institution dc.contributor.department | Állatorvostudományi Kutatóintézet | |
Author institution dc.contributor.department | Biofizikai Intézet | |
Author institution dc.contributor.department | Biokémiai Intézet |